Advances are made daily in safety research. To be able to conduct evaluations in the most appropriate way, it is essential to acquire the most-up-to-date technologies and information and to share Shiseido's technologies with experts. That is, researchers in safety assurance at Shiseido have been working with outside experts in a wide range of activities. Some of those activities are described below.
Various collaborative activities with individuals outside the company
・Interactions with outside experts
Shiseido regularly undertakes consultations on safety with Japanese and foreign experts who are active in safety assurance. Moreover, as a cosmetic company, Shiseido takes the opinions of dermatologists seriously. We actively participate in safety-related activities held by academic societies.
Shiseido takes part in events held by cosmetic industry associations around the world (e.g., Japan Cosmetic Industry Association, Cosmetics Europe (CE) , Personal Care Products Council (PCPC) , ASEAN Cosmetic Association) ,and actively exchange information related to safety. Shiseido also actively contributes to safety-related activities organized by relevant industry associations (e.g., Japan Chemical Industry Association, Japan Soap and Detergent Association, Japan Hair Color Industry Association) in safety-related events.
・Development of professional human resources
Researchers work in safety assurance regularly receive training at universities and public research institutions and take part in symposiums and education seminars held outside of the company to improve their levels of professional expertise and expert knowledge.
・Basic research on safety
Shiseido has also been collaborating with outside organizations on research topics such as sensory irritation, sensitive skin, and the development of hypo-irritant compounds that are the foundations of safety, and the results have been useful in our efforts to develop safe, secure and reliable products.
Shiseido’s commitment on alternatives to animal experiments
・Sharing of research findings
Shiseido shares with the public the findings obtained from years of research by publishing them on this website, in the literature and in academic conferences. In addition, Shiseido also makes all test methods available for external use, including the patented core technology of h-CLAT, developed jointly with Kao Corporation (all royalties from the core technology of h-CLAT have been donated to Japanese Society for Alternatives to Animal Experiments). Through such efforts, alternative test methods developed with Shiseido are expected to be widely used in a greater number of research institutions and are expected to see further improvements. For any inquiries regarding this issue, please
Reference: Initiatives in Response to Animal Testing and Alternative Methods
・Further research on alternative methods
Efforts to find alternative methods are ongoing at Shiseido with the aims of further improving precision and expanding the domain of applicability. Shiseido has also taken on the challenge in developing alternative in vitro methods for evaluating long-term systemic toxicity.
・Efforts on establishing officially acceptable methods and industry standards
Shiseido has been pushing for the establishment of an officially acceptable alternative methods for eye irritation and skin sensitization testing. Specifically, Shiseido has been taking part in the validation activities of the Japanese Center for the Validation of Alternative Methods (JaCVAM) and the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and working as a member of the OECD’s expert team to draw up guidance proposals. In addition, Shiseido has also been actively participating in the industry’s efforts to standardize alternative methods and to increase public awareness.
<Studies and other works that have received awards from the Japanese Society
for Alternatives to Animal Experiments, among other organizations>
Academic conference presentations (2013)
Society of Toxicology
52nd Annual Meeting, March 10–14, 2013
Safety assessment of cosmetics using alternative methods
-skin sensitization evaluation-
Approach to Photoallergenicity Assay for Cosmetic Ingredients
Using Non-Animal Methods
- Safety assessment of cosmetics using alternative methods
The 38th Annual Meeting of Japanese Cosmetic Science Society, June 6, 2013
- Approach to Systemic Toxicity evaluation for cosmetics without depending on animal experiments
The 40th Annual Meeting of the Japanese Society of Toxicology, June 17–19, 2013
- The use of ROS assay in photosafety evaluations of cosmetic ingredients
International Congress of Toxicology 2013, June 30 to July 4, 2013
- Development of a non-animal safety assessment system in Shiseido
The 73rd SCCJ Workshop, November 29, 2013
- Development of in vitro methods for phototoxicity and photosensitization evaluations
The 26th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments, December 19–21, 2013
- Approach to skin sensitization risk assessments using neural network analysis (I) – in vitro analysis -
- Approach to skin sensitization risk assessments using neural network analysis (II) – in silico analysis -
- In silico genotoxicity assessment prediction