Advances are made daily in safety research. To be able to conduct evaluations in the most appropriate way, it is essential to acquire the most-up-to-date technologies and information and to share Shiseido's technologies with experts. That is, researchers in safety assurance at Shiseido have been working with outside experts in a wide range of activities. Some of those activities are described below.
Shiseido regularly undertakes consultations on safety with Japanese and foreign experts who are active in safety assurance. Moreover, as a cosmetics company, Shiseido takes the opinions of dermatologists seriously. We actively participate in safety-related activities held by academic societies.
Shiseido takes part in events held by cosmetics industry associations around the world (e.g., Japan Cosmetic Industry Association, Cosmetics Europe (CE), Personal Care Products Council (PCPC), ASEAN Cosmetics Association (opens in new window)), and actively exchanges information related to safety. Shiseido also actively contributes to safety-related activities organized by relevant industry associations (e.g., Japan Chemical Industry Association, Japan Soap and Detergent Association, Japan Hair Color Industry Association).
Researchers working in safety assurance regularly receive training at universities and public research institutions and take part in symposiums and education seminars held outside of the company to improve their levels of professional expertise and expert knowledge.
Shiseido has also been collaborating with outside organizations on research topics that are the foundations of safety, such as sensory irritation, sensitive skin, and the development of hypo-irritant compounds, and the results have been useful in our efforts to develop safe, secure and reliable products.
Shiseido shares findings obtained from years of research not only on this website, but also through contributing to academic literature and participating in conferences. We strongly hope that due to such efforts, alternative testing methods developed by Shiseido become widely used by a greater number of research institutions, and will continue to improve.
Shiseido continues to proceed with its research on alternative testing methods with an aim to further improve measurement accuracy regarding the use of ingredients, and expand the scope of testing while challenging itself to develop alternative in vitro/in silico testing methods for assessing systemic toxicity.
Shiseido strives for the popularization of alternatives to skin sensitization testing and photosensitization testing. Specifically, we have taken part in validation activities conducted by the Japanese Center for the Validation of Alternative Methods (JaCVAM) and the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), and contributed to the preparation of guidance proposals for alternative methods of testing as a member of the expert team of the Organization for Economic Co-operation and Development (OECD). As a result of such efforts, h-CLAT, an alternative to skin sensitization testing was listed in the OECD testing guidelines in July 2016. In addition, the ROS assay was included in OECD testing guidelines in 2019 as an alternative to photosensitization testing after the University of Shizuoka and Shiseido examined this testing method. Shiseido will continue to aggressively promote the standardization of alternative methods, and conduct various activities to increase social awareness about these alternative methods.
<Research commended by specialized academic societies, etc>
Year | Shiseido’s studies that have contributed to the development of alternative methods and safety evaluation |
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2018 | ・In silico risk assessment for skin sensitization using artificial neural network analysis |
2016 | ・Safety assessment of Cosmetic Ingredients by Hand1-Luciferase Embryonic Stem cell Tests ・Application of photo-KeratinoSens to Integrated Testing Strategy of photosensitization ・In silico risk assessment for human percutaneous absorption and skin sensitization of drug ・In silico risk assessment for skin sensitization using artificial neural network analysis |
2015 | ・Specificity evaluation of Embryonic Stem cell Test for cosmetic ingredients |
2014 | ・Development of h-CLAT, an alternative to skin sensitization test (jointly awarded the JCIA Special Award in Technology with Kao Corporation) |
2011 | ・Study on cell-surface SH groups as a marker in an alternative skin sensitization test (SH test) |
2008 | ・Study on an eye irritation evaluation method based on a combination of SIRC-CVS test and the three-dimensional cultured skin model test |
2005 | ・Joint study in Japan on the in vitro skin sensitization test: h-CLAT (human Cell Line Activation Test) ・Study on the effect of light in in vitro phototoxicity tests |
2003 | ・Study on alternative methods of acute toxicity testing using cultured cells |
2002 | ・Study on the development of a formula for predicting percutaneous absorption and its application in predicting sensitization potentials |
2001 | ・Study on an in vitro sensitization test that measures the expression of CD86 and MHC class II as markers in the THP-1 human monocytic cell line |
2000 | ・Study on the induction of unscheduled DNA synthesis in the epidermis by skin carcinogens |
1999 | ・Study on cell line differences in photocytotoxicity tests |
1997 | ・Study on the use of the cytotoxicity test of poorly soluble substances as an alternative method for skin irritation testing |
1996 | ・Study on the use of quantitative measurement of pro-inflammatory cytokine gene expression as an alternative method for skin irritation testing |
1994 | ・Study on the application of electrophysiological techniques and other techniques on neuronal cells for use as an in vitro sensory irritation test |
1992 | ・Study on in vitro phototoxicity tests with red blood cells and yeasts |
1991 | ・Study on an in vitro test of eye irritation using hemoglobin as a biomarker ・Study on the use of liposomes prepared from lipids extracts of the cornea as an alternative for eye irritation testing |
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